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HERTHENA-Breast-01: A Phase 1b/2, Multicenter, Open-label, Dose-Finding Study to Evaluate the Safety and Antitumor Activity of Patritumab Deruxtecan in Participants With HER2 Positive Unresectable Locally Advanced Breast Cancer or Metastatic Breast Cancer

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Trial Profile

HERTHENA-Breast-01: A Phase 1b/2, Multicenter, Open-label, Dose-Finding Study to Evaluate the Safety and Antitumor Activity of Patritumab Deruxtecan in Participants With HER2 Positive Unresectable Locally Advanced Breast Cancer or Metastatic Breast Cancer

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 19 Dec 2024

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At a glance

  • Drugs Patritumab Deruxtecan (Primary) ; Trastuzumab (Primary) ; Trastuzumab-deruxtecan (Primary) ; Tucatinib (Primary)
  • Indications Advanced breast cancer; HER2 positive breast cancer
  • Focus Adverse reactions
  • Acronyms HERTHENA-Breast-01
  • Sponsors Merck Sharp & Dohme

    • Most Recent Events

    • 11 Dec 2024 Planned End Date changed from 26 Jun 2029 to 3 Sep 2029.
    • 11 Dec 2024 Planned primary completion date changed from 26 Jun 2029 to 3 Sep 2029.
    • 11 Dec 2024 Planned initiation date changed from 19 Dec 2024 to 19 Feb 2025.

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