Trial Profile

HERTHENA-Breast-01: A Phase 1b/2, Multicenter, Open-label, Dose-Finding Study to Evaluate the Safety and Antitumor Activity of Patritumab Deruxtecan in Participants With HER2 Positive Unresectable Locally Advanced Breast Cancer or Metastatic Breast Cancer

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 26 Jun 2025

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At a glance

Drugs Patritumab Deruxtecan (Primary) ; Trastuzumab (Primary) ; Trastuzumab-deruxtecan (Primary) ; Tucatinib (Primary)
Indications Advanced breast cancer; HER2 positive breast cancer
Focus Adverse reactions
Acronyms HERTHENA-Breast-01
Sponsors Merck Sharp & Dohme

13 Mar 2025 Status changed from not yet recruiting to recruiting.
08 Jan 2025 Planned End Date changed from 3 Sep 2029 to 10 Sep 2029.
08 Jan 2025 Planned primary completion date changed from 3 Sep 2029 to 10 Sep 2029.

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