Trial Profile

A Double-Blind, Placebo-Controlled, Double-Dummy Study of Donanemab and RG6289 in PSEN1 E280A Mutation Carriers, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Donanemab, RG6289, or the Combination of Donanemab and RG6289, in the Treatment of Autosomal-Dominant Alzheimer's Disease

Status: Not yet recruiting

Phase of Trial: Phase II/III

Latest Information Update: 19 Aug 2025

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At a glance

03 Aug 2025 Planned End Date changed from 1 Dec 2030 to 1 Jun 2030.
03 Aug 2025 Planned primary completion date changed from 1 Dec 2030 to 1 Jun 2030.
03 Aug 2025 Planned initiation date changed from 1 Dec 2025 to 15 Jan 2026.

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