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A Double-Blind, Placebo-Controlled, Double-Dummy Study of Donanemab and RG6289 in PSEN1 E280A Mutation Carriers, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Donanemab, RG6289, or the Combination of Donanemab and RG6289, in the Treatment of Autosomal-Dominant Alzheimer's Disease

Trial Profile

A Double-Blind, Placebo-Controlled, Double-Dummy Study of Donanemab and RG6289 in PSEN1 E280A Mutation Carriers, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Donanemab, RG6289, or the Combination of Donanemab and RG6289, in the Treatment of Autosomal-Dominant Alzheimer's Disease

Status: Not yet recruiting
Phase of Trial: Phase II/III

Latest Information Update: 03 Jun 2025

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At a glance

  • Drugs Donanemab (Primary) ; RG 6289 (Primary)
  • Indications Alzheimer's disease
  • Focus Therapeutic Use

Most Recent Events

  • 21 Nov 2024 New trial record
  • 14 Nov 2024 According to Banner Alzheimer's Institute Media release ,This study builds on the history, partnership, infrastructure and learnings of the original API ADAD Colombia Trial
  • 14 Nov 2024 According to Banner Alzheimer's Institute Media release , Lilly and Roche are generously donating the drug supplies

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