Trial Profile

Phase I/II Study of Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 10 Dec 2025

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At a glance

Drugs Azacitidine (Primary) ; Durvalumab (Primary) ; Carboplatin; Cisplatin; Gemcitabine; Paclitaxel; Pemetrexed
Indications Non-small cell lung cancer
Focus Adverse reactions; Therapeutic Use

05 Dec 2025 Planned initiation date changed from 26 Nov 2025 to 10 Dec 2025.
14 Nov 2025 Planned initiation date changed to 26 Nov 2025.
31 Oct 2025 Planned initiation date changed from 29 Oct 2025 to 5 Nov 2025.

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