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A Phase 1, Placebo-controlled, Blinded, Dose-escalation Study to Evaluate the Safety and Immunogenicity of mRNAs Encoding HIV Immunogens (eOD-GT8 60mer, Core-g28v2 60mer, N332-GT5 gp151) in Adult Participants Without HIV and in Overall Good Health in South Africa

Trial Profile

A Phase 1, Placebo-controlled, Blinded, Dose-escalation Study to Evaluate the Safety and Immunogenicity of mRNAs Encoding HIV Immunogens (eOD-GT8 60mer, Core-g28v2 60mer, N332-GT5 gp151) in Adult Participants Without HIV and in Overall Good Health in South Africa

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 22 Feb 2026

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At a glance

  • Drugs EOD-GT8 60mer (Primary)
  • Indications HIV infections
  • Focus Adverse reactions; Pharmacodynamics
  • Acronyms IAVI G004

Most Recent Events

  • 15 Jan 2026 Planned primary completion date changed from 30 Oct 2026 to 8 Dec 2026.
  • 15 Dec 2025 Planned End Date changed from 19 Dec 2025 to 31 Mar 2027.
  • 15 Dec 2025 Planned primary completion date changed from 19 Dec 2025 to 30 Oct 2026.

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