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A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab (ESSENCE)

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Trial Profile

A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab (ESSENCE)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 22 Apr 2026

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At a glance

  • Drugs Tezepelumab (Primary)
  • Indications Nasal polyps; Rhinosinusitis
  • Focus Registrational; Therapeutic Use
  • Acronyms ESSENCE
  • Sponsors AstraZeneca

Most Recent Events

  • 20 Mar 2026 Planned End Date changed from 29 Jan 2027 to 13 Jan 2027.
  • 20 Mar 2026 Planned primary completion date changed from 29 Jan 2027 to 13 Jan 2027.
  • 19 Mar 2025 Planned number of patients changed from 200 to 180.

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