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A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab (ESSENCE)

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Trial Profile

A Multicentre, Single-Arm, Phase 3b Study to Assess Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With Tezepelumab (ESSENCE)

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Aug 2026

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At a glance

  • Drugs Tezepelumab (Primary)
  • Indications Nasal polyps; Rhinosinusitis
  • Focus Registrational; Therapeutic Use
  • Acronyms ESSENCE
  • Sponsors AstraZeneca; AstraZeneca AB

Most Recent Events

  • 10 Jun 2026 Status changed from recruiting to active, no longer recruiting.
  • 20 Mar 2026 Planned End Date changed from 29 Jan 2027 to 13 Jan 2027.
  • 20 Mar 2026 Planned primary completion date changed from 29 Jan 2027 to 13 Jan 2027.

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