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A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Expansion Study of the Oral DNA Helicase Werner Inhibitor (WRNi) GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Adult Participants With Mismatch Repair-deficient (dMMR) or Microsatellite Instability-High (MSI-H) Solid Tumors (SYLVER)

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A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Expansion Study of the Oral DNA Helicase Werner Inhibitor (WRNi) GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Adult Participants With Mismatch Repair-deficient (dMMR) or Microsatellite Instability-High (MSI-H) Solid Tumors (SYLVER)

Status: Not yet recruiting
Phase of Trial: Phase I/II

Latest Information Update: 05 Dec 2024

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At a glance

  • Drugs GSK-4418959 (Primary)
  • Indications Colorectal cancer; Endometrial cancer; Solid tumours
  • Focus Adverse reactions; First in man; Therapeutic Use
  • Acronyms SYLVER
  • Sponsors GSK

    • Most Recent Events

    • 05 Dec 2024 New trial record

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