Trial Profile

A Phase 1/2 First-Time-in-Human, Open-label, Multicenter, Dose Escalation and Expansion Study of the Oral DNA Helicase Werner Inhibitor (WRNi) GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Adult Participants With Mismatch Repair-deficient (dMMR) or Microsatellite Instability-High (MSI-H) Solid Tumors (SYLVER)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 04 Jun 2025

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At a glance

Drugs GSK 4418959 (Primary)
Indications Colon cancer; Colorectal cancer; Endometrial cancer; Rectal cancer; Solid tumours
Focus Adverse reactions; First in man; Therapeutic Use
Acronyms SYLVER
Sponsors GSK

30 Apr 2025 Trial design presented at the 116th Annual Meeting of the American Association for Cancer Research.
04 Feb 2025 Planned End Date changed from 29 Jun 2028 to 16 Jun 2028.
04 Feb 2025 Planned primary completion date changed from 1 Mar 2027 to 16 Feb 2027.

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