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A Phase 1/2 Clinical Trial of the Novel Topoisomerase I Inhibitor PEEL-224 as a Single Agent and in Combination With Vincristine and Temozolomide in Children With Refractory, Progressive or Relapsed Solid Tumors

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Trial Profile

A Phase 1/2 Clinical Trial of the Novel Topoisomerase I Inhibitor PEEL-224 as a Single Agent and in Combination With Vincristine and Temozolomide in Children With Refractory, Progressive or Relapsed Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Jul 2026

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At a glance

  • Drugs PEG [SN22]4 (Primary) ; Temozolomide; Vincristine
  • Indications CNS cancer; Neuroblastoma; Rhabdomyosarcoma; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms PEEL-224

Most Recent Events

  • 13 Mar 2025 Status changed from not yet recruiting to recruiting.
  • 11 Dec 2024 New trial record

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