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A Phase 1/2 Study of KB304, a Replication-Defective, Non-Integrating Vector Expressing Human Type III Collagen (COL3) and Tropoelastin for the Treatment of Wrinkles

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Trial Profile

A Phase 1/2 Study of KB304, a Replication-Defective, Non-Integrating Vector Expressing Human Type III Collagen (COL3) and Tropoelastin for the Treatment of Wrinkles

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 21 May 2025

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At a glance

  • Drugs JN 304 (Primary) ; Sodium chloride
  • Indications Skin wrinkles
  • Focus Therapeutic Use
  • Acronyms Pearl-2
  • Sponsors Krystal Biotech

Most Recent Events

  • 13 May 2025 Planned primary completion date changed from 1 May 2025 to 1 Jul 2025.
  • 13 May 2025 Status changed from recruiting to active, no longer recruiting.
  • 06 May 2025 According to a Krystal Biotech media release, In February, Jeune Aesthetics completed enrollment in PEARL-2, an ongoing, randomized and placebo-controlled Phase 1 study evaluating KB304 for the treatment of wrinkles.

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