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A Phase 1 open-label trial to evaluate the safety, tolerability, PK, PD, immunogenicity, and preliminary antitumor activity of LAVA-1266, a CD123-targeting bispecific gamma delta-T cell engager, in patients with CD123 positive R/R AML and intermediate risk, high risk, or extremely high risk MDS

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Trial Profile

A Phase 1 open-label trial to evaluate the safety, tolerability, PK, PD, immunogenicity, and preliminary antitumor activity of LAVA-1266, a CD123-targeting bispecific gamma delta-T cell engager, in patients with CD123 positive R/R AML and intermediate risk, high risk, or extremely high risk MDS

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 15 Jan 2025

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At a glance

  • Drugs LAVA 1266 (Primary)
  • Indications Acute myeloid leukaemia; Myelodysplastic syndromes
  • Focus Adverse reactions; First in man
  • Sponsors Lava Therapeutics

    • Most Recent Events

    • 10 Jan 2025 According to a LAVA Therapeutics media release, company is looking forward to provide initial results from the dose escalation study by the end of the year.
    • 10 Jan 2025 According to a LAVA Therapeutics media release, company announced dosing of first patient in this Phase 1, first-in-human study of LAVA-1266, for treatment of hematologic cancers including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
    • 10 Jan 2025 Status changed to recruiting.

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