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An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva (FOP)

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Trial Profile

An Observational Study of IL1 Inhibition for Blocking ACVR1-Induced Flare Activity and Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva (FOP)

Status: Recruiting
Phase of Trial: Phase IV

Latest Information Update: 14 Aug 2026

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At a glance

  • Drugs Anakinra (Primary) ; Canakinumab (Primary)
  • Indications Fibrodysplasia ossificans progressiva
  • Focus Adverse reactions

Most Recent Events

  • 06 Aug 2026 Planned End Date changed from 1 Mar 2027 to 5 Nov 2027.
  • 06 Aug 2026 Planned primary completion date changed from 1 Mar 2027 to 5 Nov 2027.
  • 30 Dec 2025 The protocol has been amended to addition in treatment arm.

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