Trial Profile

Dose-Adjusted Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) ± Rituximab + Recombinant Erwinia Asparaginase (JZP458; Rylaze®) for the Treatment of Newly-Diagnosed Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Lymphoma/Leukemia

Status: Not yet recruiting

Phase of Trial: Phase II

Latest Information Update: 16 Jan 2026

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At a glance

Drugs Crisantaspase (Primary) ; Cyclophosphamide (Primary) ; Doxorubicin (Primary) ; Etoposide (Primary) ; Filgrastim (Primary) ; Pegfilgrastim (Primary) ; Prednisone (Primary) ; Rituximab (Primary) ; Vincristine (Primary)
Indications Precursor cell lymphoblastic leukaemia-lymphoma
Focus Therapeutic Use

13 Jan 2026 Planned initiation date changed from 1 Jan 2026 to 1 Feb 2026.
22 Dec 2025 Planned End Date changed from 30 Jun 2028 to 30 Jul 2028.
22 Dec 2025 Planned primary completion date changed from 31 Dec 2027 to 31 Jan 2028.

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