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Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study

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Trial Profile

Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 08 Sep 2026

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At a glance

  • Drugs Cadonilimab (Primary) ; Pemetrexed (Primary)
  • Indications Meningeal carcinomatosis; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 02 Sep 2026 Planned End Date changed from 30 Jul 2026 to 30 Sep 2026.
  • 02 Sep 2026 Planned primary completion date changed from 30 Jul 2026 to 30 Sep 2026.
  • 21 Jul 2026 Planned End Date changed from 1 Jun 2026 to 30 Jul 2026.

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