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Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study

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Trial Profile

Intrathecal Administration of PD-1/CTLA-4 Bispecific Antibody Plus Pemetrexed in Patients With Leptomeningeal Metastasis From Solid Tumors: A Phase I/II Study

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Cadonilimab (Primary) ; Pemetrexed (Primary)
  • Indications Meningeal carcinomatosis; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 20 May 2025 Efficacy primary end-point "Clinical response rate" has been removed.
  • 18 Mar 2025 Planned initiation date changed from 1 Feb 2025 to 1 Apr 2025.
  • 18 Mar 2025 Status changed from not yet recruiting to recruiting.

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