Trial Profile

A Phase 3 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 Compared to Alectinib in First-Line Treatment of Patients With ALK-Positive Advanced Non-Small Cell Lung Cancer (ALKAZAR)

Status: Recruiting

Phase of Trial: Phase III

Latest Information Update: 11 Dec 2025

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At a glance

17 Nov 2025 According to a Nuvalent media release, Enhanced monitoring for transaminase elevations and prompt dose interventions have been implemented in the protocol for the ALKAZAR Phase 3 randomized, controlled trial.
21 Jul 2025 According to a Nuvalent media release, company announced that the first patient has been dosed in this trial.
24 Jun 2025 According to a Nuvalent media release, the company expects to begin enrollment early in the second half of 2025.

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