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A Phase 2b, Open-label Study to Evaluate the Efficacy and Safety of Inaxaplin in Subjects With Proteinuric APOL1-mediated Kidney Disease With or Without Comorbidities That May Independently Contribute to Chronic Kidney Disease

Trial Profile

A Phase 2b, Open-label Study to Evaluate the Efficacy and Safety of Inaxaplin in Subjects With Proteinuric APOL1-mediated Kidney Disease With or Without Comorbidities That May Independently Contribute to Chronic Kidney Disease

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 24 Aug 2026

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At a glance

  • Drugs Inaxaplin (Primary)
  • Indications Kidney disorders
  • Focus Therapeutic Use
  • Acronyms AMPLIFIED
  • Sponsors Vertex Pharmaceuticals

Most Recent Events

  • 20 Aug 2026 Status changed from active, no longer recruiting to completed.
  • 05 May 2026 Status changed from recruiting to active, no longer recruiting.
  • 04 May 2026 According to Vertex pharmaceutical media release, Vertex is on track to complete dosing and share data from the AMPLIFIED study in the second half of 2026.

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