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A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Trial Profile

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Jul 2025

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At a glance

  • Drugs 4D-150 (Primary) ; Aflibercept
  • Indications Wet age-related macular degeneration
  • Focus Adverse reactions; Registrational
  • Acronyms 4FRONT-2
  • Sponsors 4D Molecular Therapeutics

Most Recent Events

  • 02 Jul 2025 According to 4DMT media release, the company announced the acceleration of the 4D-150 4FRONT Phase 3 program in wet AMD.he Company also has streamlined operations to offset additional expenses expected based on the accelerated timelines for the 4FRONT clinical trials and BLA preparation, which supports the Company's cash runway into 2028, as previously guided.
  • 02 Jul 2025 Status changed from planning to recruiting. Trial was initiated in June 2025.
  • 16 Jan 2025 New trial record

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