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A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

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Trial Profile

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 07 May 2026

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At a glance

  • Drugs 4D-150 (Primary) ; Aflibercept
  • Indications Wet age-related macular degeneration
  • Focus Registrational; Therapeutic Use
  • Acronyms 4FRONT-2
  • Sponsors 4D Molecular Therapeutics

Most Recent Events

  • 12 Feb 2026 Planned number of patients changed from 400 to 480.
  • 09 Feb 2026 According to a 4D Molecular Therapeutics media release, 4FRONT-2,has an identical design to 4FRONT-1 except for enrolling both treatment-naive and recently diagnosed treatment-experienced wet AMD patients.
  • 10 Nov 2025 According to a 4D Molecular Therapeutics media release, 52-week topline data expected in H2 2027

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