A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Latest Information Update: 26 Oct 2026
At a glance
- Drugs Zunibergene rocparvovec 4D Molecular Therapeutics/Otsuka Pharmaceutical (Primary) ; Aflibercept
- Indications Wet age-related macular degeneration
- Focus Registrational; Therapeutic Use
- Acronyms 4FRONT-2
- Sponsors 4D Molecular Therapeutics
Most Recent Events
- 19 Oct 2026 Planned End Date changed from 1 Feb 2029 to 1 Nov 2029.
- 19 Oct 2026 Planned primary completion date changed from 1 Nov 2028 to 1 Nov 2027.
- 13 Aug 2026 According to a 4D Molecular Therapeutics media release, enrollment has been completed in June 2026 with N>500 expected to be randomized.