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An Evaluation of Bemnifosbuvir-Ruzasvir (BEM/RZR) Versus Sofosbuvir-Velpatasvir (SOF/VEL) for the Treatment of Chronic Hepatitis C Virus (HCV) Infection in a Phase 3 Randomized, Controlled, Open-label Study

Trial Profile

An Evaluation of Bemnifosbuvir-Ruzasvir (BEM/RZR) Versus Sofosbuvir-Velpatasvir (SOF/VEL) for the Treatment of Chronic Hepatitis C Virus (HCV) Infection in a Phase 3 Randomized, Controlled, Open-label Study

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 25 Aug 2026

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At a glance

  • Drugs Bemnifosbuvir/Ruzasvir (Primary) ; Sofosbuvir/velpatasvir
  • Indications Hepatitis C
  • Focus Registrational; Therapeutic Use
  • Acronyms C-FORWARD
  • Sponsors Atea Pharmaceuticals

Most Recent Events

  • 12 Aug 2026 According to an Atea Pharmaceuticals media release, following the recent topline readout for C-BEYOND and pending results from C-FORWARD, Atea anticipates submitting a new drug application (NDA) to the US Food & Drug Administration (FDA) in the second quarter of 2027.
  • 28 Jul 2026 According to an Atea Pharmaceuticals media release, topline data from the trial is expected in early 2027.
  • 25 Jun 2026 Status changed from recruiting to active, no longer recruiting. C-FORWARD enrolled more than 880 treatment-naive patients across approximately 120 clinical sites in 17 countries.

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