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A Phase 1/2a, Open-label Study of VS-7375, a KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and in Combination, in Patients With Advanced KRAS G12D-Mutated Solid Tumors

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Trial Profile

A Phase 1/2a, Open-label Study of VS-7375, a KRAS G12D (ON/OFF) Inhibitor, as Monotherapy and in Combination, in Patients With Advanced KRAS G12D-Mutated Solid Tumors

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 25 Jun 2025

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At a glance

  • Drugs VS 7375 (Primary)
  • Indications Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Verastem Oncology

Most Recent Events

  • 18 Jun 2025 Status changed from not yet recruiting to recruiting.
  • 15 Jun 2025 Status changed from planning to not yet recruiting.
  • 02 Jun 2025 According to a Verastem Oncology media release, Company activating sites in the U.S. for VS-7375 to begin enrollment in the Phase 1/2a trial.

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