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PAXIS: A Randomized, Double-blind, Placebo-controlled Dose-finding Phase 2 Study (Part 1) Followed by an Open-label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients With VEXAS Syndrome

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Trial Profile

PAXIS: A Randomized, Double-blind, Placebo-controlled Dose-finding Phase 2 Study (Part 1) Followed by an Open-label Period (Part 2) to Assess the Efficacy and Safety of Pacritinib in Patients With VEXAS Syndrome

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Apr 2026

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At a glance

  • Drugs Pacritinib (Primary)
  • Indications Myelofibrosis; VEXAS syndrome
  • Focus Therapeutic Use
  • Acronyms PAXIS
  • Sponsors Swedish Orphan Biovitrum

Most Recent Events

  • 12 Mar 2026 Status changed from active, no longer recruiting to recruiting.
  • 22 Dec 2025 Planned End Date changed from 1 Aug 2027 to 22 May 2028.
  • 22 Dec 2025 Planned primary completion date changed from 1 Aug 2027 to 30 Dec 2026.

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