Trial Profile

A Phase 1/2 Open-Label, Umbrella Platform Design Study of Investigational Agents in Combination With Pembrolizumab (MK-3475) With or Without Chemotherapy in Participants With 1L Locally Advanced Unresectable/Metastatic Esophageal Cancer: KEYMAKER-U06 Substudy 06E

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 11 Jun 2025

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At a glance

Drugs Fluorouracil (Primary) ; Folinic acid (Primary) ; Ifinatamab deruxtecan (Primary) ; Levofolinic acid (Primary) ; Oxaliplatin (Primary) ; Pembrolizumab (Primary)
Indications Oesophageal cancer; Squamous cell cancer
Focus Adverse reactions; Therapeutic Use
Acronyms KEYMAKER-U06 Substudy 06E
Sponsors Merck Sharp & Dohme

04 Jun 2025 Planned number of patients changed from 209 to 228.
22 May 2025 According to Daiichi Sankyo Company media release, data from this trial will be presented at the 2025 American Society of Clinical Oncology Scientific Program (#ASCO25)
15 Apr 2025 Planned initiation date changed from 23 Apr 2025 to 7 Aug 2025.

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