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A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Compare the Safety and Efficacy of 3 Dose Levels of AV-1 in Healthy Adults Challenged With a Controlled Human Infection Strain of DENV-3

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Trial Profile

A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Compare the Safety and Efficacy of 3 Dose Levels of AV-1 in Healthy Adults Challenged With a Controlled Human Infection Strain of DENV-3

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 21 Aug 2025

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At a glance

  • Drugs AV-1 AbViro LLC (Primary)
  • Indications Dengue
  • Focus Adverse reactions; Pharmacodynamics; Therapeutic Use
  • Sponsors AbViro

Most Recent Events

  • 06 Aug 2025 Planned End Date changed from 10 Jan 2026 to 31 Mar 2026.
  • 06 Aug 2025 Planned primary completion date changed from 10 Jan 2026 to 31 Mar 2026.
  • 08 Jul 2025 Planned End Date changed from 28 Nov 2025 to 10 Jan 2026.

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