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A Phase I/II Clinical Study of Intrathecal Combination Therapy With the PD-1/VEGF Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis

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Trial Profile

A Phase I/II Clinical Study of Intrathecal Combination Therapy With the PD-1/VEGF Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 11 Jun 2025

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At a glance

  • Drugs Ivonescimab (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 20 May 2025 Efficacy primary end-points "Clinical response rate" and "Overall survival(OS)" are removed.
  • 25 Mar 2025 Planned initiation date changed from 1 Mar 2025 to 1 Sep 2025.
  • 25 Mar 2025 Status changed from not yet recruiting to recruiting.

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