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A registrational Phase 3 study of sirexatamab plus bevacizumab and chemotherapy in second-line microsatellite stable Colorectal cancer (MSS CRC) patients

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Trial Profile

A registrational Phase 3 study of sirexatamab plus bevacizumab and chemotherapy in second-line microsatellite stable Colorectal cancer (MSS CRC) patients

Status: Planning
Phase of Trial: Phase III

Latest Information Update: 11 Feb 2025

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At a glance

  • Drugs Antineoplastics (Primary) ; Bevacizumab (Primary) ; Sirexatamab (Primary)
  • Indications Colorectal cancer
  • Focus Registrational; Therapeutic Use

    • Most Recent Events

    • 11 Feb 2025 New trial record
    • 28 Jan 2025 According to Leap Therapeutics media release, positive signal from DeFianCe study supports Leap moving forward to plan a registrational Phase 3 clinical trial to evaluate sirexatamab plus bevacizumab and chemotherapy in second-line MSS CRC. Leap intends to conduct global commercial and regulatory strategic analysis to select the optimal population.

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