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Intrathecal Administration of Double Checkpoint Inhibition in Combination with Pemetrexed in Patients with Leptomeningeal Metastasis: a Monocentric Phase I/II

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Trial Profile

Intrathecal Administration of Double Checkpoint Inhibition in Combination with Pemetrexed in Patients with Leptomeningeal Metastasis: a Monocentric Phase I/II

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 31 Mar 2025

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At a glance

  • Drugs Iparomlimab/tuvonralimab (Primary) ; Pemetrexed (Primary)
  • Indications Solid tumours
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 26 Mar 2025 Planned initiation date (estimated date for recruitment of the first subject) changed from 1 Mar 2025 to 1 Sep 2025.
  • 26 Mar 2025 Status changed from not yet recruiting to recruiting.
  • 11 Feb 2025 New trial record

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