Trial Profile

A Phase 1/1b, Open-Label, Multicenter, First-in-Human Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-Tumor Activity of VVD-159642, a RAS-PI3Kα Inhibitor, as a Single Agent and in Combination in Participants With Advanced Solid Tumors

Status: Recruiting

Phase of Trial: Phase I

Latest Information Update: 20 Jun 2025

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At a glance

Drugs Sotorasib (Primary) ; Trametinib (Primary) ; VVD 159642 (Primary)
Indications Adenocarcinoma; Colorectal cancer; Non-small cell lung cancer; Pancreatic ductal carcinoma; Solid tumours
Focus Adverse reactions; First in man
Sponsors Vividion Therapeutics

03 Apr 2025 According to Vividion Therapeutics media release, first patient has been dosed in this study.
20 Mar 2025 Status changed from not yet recruiting to recruiting.
12 Feb 2025 New trial record

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