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A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer

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Trial Profile

A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 04 Jul 2026

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At a glance

  • Drugs Trastuzumab-deruxtecan (Primary) ; Bevacizumab
  • Indications Breast cancer; Fallopian tube cancer; Gastric cancer; Ovarian cancer; Peritoneal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms DESTINY-Ovarian01; DO-01; ENGOT-ov89
  • Sponsors Daiichi Sankyo Company

Most Recent Events

  • 02 Jun 2026 Results presented at the 62nd Annual Meeting of the American Society of Clinical Oncology
  • 09 Dec 2025 According to Daiichi Sankyo company media release, DESTINY-Ovarian01 is being conducted in collaboration with the European Network of Gynecological Oncological Trial Groups (ENGOT), with the Spanish cooperative group (GEICO) as the lead ENGOT group, The GOG Foundation, Inc. (GOG-F) and Asia-Pacific Gynecologic Oncology Trials Group (APGOT).
  • 09 Dec 2025 According to Daiichi Sankyo company media release, The first patient has been dosed in the randomization phase of the DESTINY-Ovarian01 phase 3 trial.

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