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A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)

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Trial Profile

A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 13 Oct 2025

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At a glance

  • Drugs Carboplatin (Primary) ; Datopotamab deruxtecan (Primary) ; Pembrolizumab (Primary)
  • Indications Non-small cell lung cancer
  • Focus Therapeutic Use
  • Acronyms TROPICAL-1

Most Recent Events

  • 29 Sep 2025 Planned End Date changed from 28 Feb 2029 to 1 Nov 2028.
  • 29 Sep 2025 Planned primary completion date changed from 31 Jul 2028 to 30 Jun 2028.
  • 29 Sep 2025 Planned initiation date changed from 30 Jun 2025 to 30 Sep 2025.

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