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A Phase Ib trial evaluating NXP900 as monotherapy in YES1/SRC-driven solid tumors, and in combination with EGFR and ALK inhibitors, in patients with non-small cell lung cancer

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Trial Profile

A Phase Ib trial evaluating NXP900 as monotherapy in YES1/SRC-driven solid tumors, and in combination with EGFR and ALK inhibitors, in patients with non-small cell lung cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 09 Dec 2025

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At a glance

  • Drugs Anaplastic lymphoma kinase inhibitors (Primary) ; NXP 900 (Primary) ; Osimertinib (Primary)
  • Indications Non-small cell lung cancer; Solid tumours
  • Focus Adverse reactions

Most Recent Events

  • 25 Nov 2025 According to Nuvectis Pharma media release, the company will host a virtual Key Opinion Leader Meeting on Tuesday, December 2, 2025 at 8:00 AM ET to discuss the NXP900 Phase 1b Program in Advanced Solid Tumors, including the combination with osimertinib in non-small cell lung cancer.
  • 11 Aug 2025 According to Nuvectis Pharma media release, The Phase 1b program was initiated following the successful completion of a dose escalation study in patients with advanced solid tumors and a clinical drug-drug interaction study in healthy volunteer, and is intended to include a single agent component, which is now underway, and a combination component that is expected to commence later this year.
  • 11 Aug 2025 Status changed from planning to recruiting. as per Nuvectis Pharma media release.

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