Trial Profile

A Phase 1b/2 Open-label, Multicenter Study to Evaluate the Safety and Efficacy of Raludotatug Deruxtecan With or Without Other Anticancer Investigational Agents in Participants With High-grade Serous Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Have Relapsed After Prior Platinum-based Chemotherapy

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 29 Jul 2026

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At a glance

Drugs Bevacizumab (Primary) ; Carboplatin (Primary) ; Paclitaxel (Primary) ; Raludotatug deruxtecan (Primary)
Indications Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
Focus Adverse reactions
Sponsors Merck Sharp & Dohme

13 May 2026 Planned number of patients changed from 280 to 460.
23 Oct 2025 Planned number of patients changed from 78 to 280.
11 Apr 2025 Planned initiation date changed from 27 Mar 2025 to 11 Apr 2025.

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