Trial Profile

A Multicenter Phase 2 Study of Zanubrutinib, Obinutuzumab, and Sonrotoclax (BOSon) or Tacabrutideg (BGB-16673), Obinutuzumab, and Sonrotoclax (DOSon) in Treatment-Naïve Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Status: Recruiting

Phase of Trial: Phase II

Latest Information Update: 13 Aug 2026

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At a glance

Drugs Obinutuzumab (Primary) ; Sonrotoclax (Primary) ; Zanubrutinib (Primary)
Indications Chronic lymphocytic leukaemia
Focus Adverse reactions; Therapeutic Use
Acronyms BOSon

22 Jul 2026 Protocol has been amended one new arm (Experimental: Catadegbrutinib (BGB-16673), Obinutuzumab, and Sonrotoclax (DOSon)) , it has changed 1 to 2.
22 Jul 2026 Planned number of patients changed from 40 to 80.
25 Sep 2025 Status changed from not yet recruiting to recruiting.

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