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A Phase 1, Open-Label Study to Evaluate the Mutual Drug-Drug Interaction Potential Between Denifanstat and Resmetirom in Healthy Adult Participants

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Trial Profile

A Phase 1, Open-Label Study to Evaluate the Mutual Drug-Drug Interaction Potential Between Denifanstat and Resmetirom in Healthy Adult Participants

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 21 Oct 2025

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At a glance

  • Drugs Denifanstat (Primary) ; Resmetirom (Primary)
  • Indications Acne vulgaris; Astrocytoma; Breast cancer; Glioblastoma; Liver cancer; Liver disorders; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Non-small cell lung cancer; Prostate cancer
  • Focus Pharmacokinetics
  • Sponsors Sagimet Biosciences

Most Recent Events

  • 16 Oct 2025 Status changed from recruiting to active, no longer recruiting.
  • 14 Oct 2025 Status changed from planning to recruiting.
  • 01 Oct 2025 According to a Sagimet Biosciences media release, Topline data from this trial are anticipated in the first half of 2026 and, if positive, are planned to be used to advance the development of the combination for patients living with metabolic dysfunction-associated steatohepatitis (MASH) into Phase 2, subject to consultation with regulatory authorities.

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