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Short-course Neoadjuvant Radiotherapy Combined With Chemotherapy and Iparomlimab and Tuvonralimab in Microsatellite Stability (MSS) or Mismatch-repair-proficient (pMMR) Patients With Locally Advanced Rectal Cancer: A Randomized Controlled Clinical Study

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Trial Profile

Short-course Neoadjuvant Radiotherapy Combined With Chemotherapy and Iparomlimab and Tuvonralimab in Microsatellite Stability (MSS) or Mismatch-repair-proficient (pMMR) Patients With Locally Advanced Rectal Cancer: A Randomized Controlled Clinical Study

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Jan 2026

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At a glance

  • Drugs Iparomlimab/tuvonralimab (Primary) ; Capecitabine; Oxaliplatin
  • Indications Adenocarcinoma; Rectal cancer
  • Focus Therapeutic Use

Most Recent Events

  • 14 Jan 2026 Status changed from not yet recruiting to recruiting.
  • 03 Apr 2025 Planned initiation date changed from 1 Mar 2025 to 1 May 2025.
  • 11 Mar 2025 New trial record

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