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Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis (SHASTA-5 Study)

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Trial Profile

Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia at High Risk of Acute Pancreatitis (SHASTA-5 Study)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 24 Sep 2026

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At a glance

  • Drugs Plozasiran (Primary)
  • Indications Hypertriglyceridaemia
  • Focus Registrational; Therapeutic Use
  • Acronyms SHASTA-5
  • Sponsors Arrowhead Pharmaceuticals

Most Recent Events

  • 13 Jul 2026 Planned number of patients changed from 378 to 476.
  • 22 Jun 2026 Planned number of patients changed from 288 to 378.
  • 10 Sep 2025 Planned primary completion date changed from 1 Mar 2028 to 1 Mar 2029.

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