Trial Profile

A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in Participants With Early or Acute Hematogenous PJI Requiring or Not Requiring DAIR After TKA, or Requiring Long-term Antibiotic Therapy

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 10 Mar 2026

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At a glance

Drugs Levofloxacin (Primary) ; Minocycline (Primary) ; Rifampicin (Primary) ; Rifaquizinone (Primary) ; Vancomycin (Primary) ; Vancomycin (Primary)
Indications Bone and joint infections; Gram-positive infections; Methicillin-resistant Staphylococcus aureus infections
Focus Adverse reactions; Proof of concept
Sponsors TenNor Therapeutics

05 Mar 2026 Status changed from completed to recruiting.
03 Mar 2026 Status changed from recruiting to completed.
08 Sep 2025 Number of treatment arms are increased from 3 to 4 by the addition of Experimental: Expansion group arm, with 10 additional planned patients.

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