Trial Profile

A Phase 1/2, Randomized, Controlled, Open-label, Proof-of-concept Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Efficacy of TNP-2092 Administered Via Intra-articular Injection (IA) in Adult Participants With Early or Acute Hematogenous Prosthetic Joint Infection (PJI) Requiring or Not Requiring Debridement, Antibiotics, and Implants Retention (DAIR) After Total Knee Arthroplasty (TKA)

Status: Recruiting

Phase of Trial: Phase I/II

Latest Information Update: 11 Apr 2025

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At a glance

Drugs Levofloxacin (Primary) ; Minocycline (Primary) ; Rifampicin (Primary) ; Rifaquizinone (Primary) ; Vancomycin (Primary) ; Vancomycin (Primary)
Indications Bone and joint infections; Gram-positive infections; Methicillin-resistant Staphylococcus aureus infections
Focus Adverse reactions; Proof of concept
Sponsors TenNor Therapeutics

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