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A Phase 3 Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide (ECLIPSE 2)

Trial Profile

A Phase 3 Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide (ECLIPSE 2)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 20 Nov 2025

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At a glance

  • Drugs Elebsiran (Primary) ; Tobevibart (Primary) ; Bulevirtide
  • Indications Hepatitis D
  • Focus Registrational; Therapeutic Use
  • Acronyms ECLIPSE 2
  • Sponsors Vir Biotechnology

Most Recent Events

  • 05 Nov 2025 According to Vir Biotechnology media release, topline data expected in the first quarter of 2027.
  • 07 Oct 2025 According to Vir Biotechnology media release, data from the trial will be presented at the upcoming American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2025 in Washington, D.C., November 7-11.
  • 19 Aug 2025 Status changed from planning to recruiting.

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