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A Phase 2b Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy Versus Bulevirtide in Participants With Chronic HDV Infection (ECLIPSE 3)

Trial Profile

A Phase 2b Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy Versus Bulevirtide in Participants With Chronic HDV Infection (ECLIPSE 3)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 14 Nov 2025

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At a glance

  • Drugs Elebsiran (Primary) ; Tobevibart (Primary) ; Bulevirtide
  • Indications Hepatitis D
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ECLIPSE 3
  • Sponsors Vir Biotechnology

Most Recent Events

  • 05 Nov 2025 According to Vir Biotechnology media release, topline data expected in the first quarter of 2027.
  • 07 Oct 2025 According to Vir Biotechnology media release, data from the trial will be presented at the upcoming American Association for the Study of Liver Diseases (AASLD) The Liver Meeting 2025 in Washington, D.C., November 7-11.
  • 06 Aug 2025 According to a Vir Biotechnology media release, this trial ECLIPSE 3 will provide important supportive data to help establish access and reimbursement in key markets.

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