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A Phase 2b Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy Versus Bulevirtide in Participants With Chronic HDV Infection (ECLIPSE 3)

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Trial Profile

A Phase 2b Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Tobevibart+Elebsiran Combination Therapy Versus Bulevirtide in Participants With Chronic HDV Infection (ECLIPSE 3)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 18 Sep 2025

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At a glance

  • Drugs Elebsiran (Primary) ; Tobevibart (Primary) ; Bulevirtide
  • Indications Hepatitis D
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms ECLIPSE 3
  • Sponsors Vir Biotechnology

Most Recent Events

  • 24 Jun 2025 Status changed from planning to recruiting.
  • 26 Mar 2025 New trial record
  • 13 Mar 2025 According to a Vir Biotechnology media release, this study is a part of the company's registrational program named ECLIPSE, comprised of two Phase 3 studies (ECLIPSE 1 and ECLIPSE 2) and one phase 2b study (ECLIPSE 3). ECLIPSE program is designed to enable regulatory submissions to multiple regulatory agencies and to support reimbursement and access. ECLIPSE 1 and 2 will provide the registrational efficacy and safety data; ECLIPSE 3 will provide important supportive data.

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