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A Phase 3, Multicenter, Randomized, Open-label Trial of Trastuzumab Deruxtecan in Combination With Pembrolizumab Versus Platinum-based Chemotherapy in Combination With Pembrolizumab, as First-line Therapy in Participants With Locally Advanced Unresectable or Metastatic HER2 Overexpressing and PD-L1 TPS <50% Non-squamous Non-small Cell Lung Cancer (DESTINY-Lung06)

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Trial Profile

A Phase 3, Multicenter, Randomized, Open-label Trial of Trastuzumab Deruxtecan in Combination With Pembrolizumab Versus Platinum-based Chemotherapy in Combination With Pembrolizumab, as First-line Therapy in Participants With Locally Advanced Unresectable or Metastatic HER2 Overexpressing and PD-L1 TPS <50% Non-squamous Non-small Cell Lung Cancer (DESTINY-Lung06)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Oct 2025

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At a glance

  • Drugs Pembrolizumab (Primary) ; Trastuzumab-deruxtecan (Primary) ; Carboplatin; Cisplatin; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms DESTINY-Lung06
  • Sponsors Daiichi Sankyo Company

Most Recent Events

  • 22 Sep 2025 Planned initiation date (estimated date for recruitment of the first subject) changed from 7 Sep 2025 to 7 Oct 2025.
  • 22 Sep 2025 Status changed from not yet recruiting to recruiting.
  • 14 Aug 2025 According to Daiichi Sankyo media release, company will present data from this trial in poster session at the IASLC 2025 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (#WCLC25) on Tuesday, September 9.

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