Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
Latest Information Update: 04 Aug 2026
At a glance
- Drugs Ketoprofen (Primary) ; Pentoxifylline (Primary) ; Pirfenidone (Primary) ; Pravastatin (Primary) ; Tocopherol (Primary)
- Indications Head and neck cancer
- Focus Adverse reactions
- Acronyms Reverse-fibrose
Most Recent Events
- 24 Jul 2026 Planned End Date changed from 1 Mar 2033 to 31 Jul 2031.
- 24 Jul 2026 Planned primary completion date changed from 1 Mar 2031 to 31 Jul 2030.
- 10 Oct 2025 Status changed from not yet recruiting to recruiting.