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Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

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Trial Profile

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Status: Recruiting
Phase of Trial: Phase II

Latest Information Update: 16 Oct 2025

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At a glance

  • Drugs Ketoprofen (Primary) ; Pentoxifylline (Primary) ; Pirfenidone (Primary) ; Pravastatin (Primary) ; Tocopherol (Primary)
  • Indications Head and neck cancer
  • Focus Adverse reactions

Most Recent Events

  • 10 Oct 2025 Status changed from not yet recruiting to recruiting.
  • 09 Apr 2025 New trial record

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