Trial Profile

A Phase 1/2 Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Trial to Assess the Safety, Tolerability, Pharmacodynamics, and Preliminary Efficacy of AFTX-201 Administered to Adult Participants With BCL2-Associated Athanogene 3 (BAG3) Mutation-Associated Dilated Cardiomyopathy: UPBEAT Trial

Status: Not yet recruiting

Phase of Trial: Phase I/II

Latest Information Update: 03 Mar 2026

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At a glance

23 Feb 2026 Status changed from planning to not yet recruiting.
04 Feb 2026 According to Affinia Therapeutics media release, company is looking forward to initiate the UPBEAT clinical trial at multiple trial sites in the coming weeks
04 Feb 2026 According to Affinia Therapeutics media release, company announced that the U.S. Food and Drug Administration (FDA) has accepted its Investigational New Drug (IND) application for AFTX-201, an investigational genetic medicine for the treatment of BAG3 DCM.

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