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A Phase 1, Randomized, Open-label, Parallel, Single-dose Study to Assess the Pharmacokinetics, Tolerability, and Absolute Bioavailability of Subcutaneous Administration of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Healthy Participants

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Trial Profile

A Phase 1, Randomized, Open-label, Parallel, Single-dose Study to Assess the Pharmacokinetics, Tolerability, and Absolute Bioavailability of Subcutaneous Administration of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Healthy Participants

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 14 Oct 2025

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At a glance

  • Drugs BMS 986446 (Primary) ; BMS 986446 (Primary) ; Loratadine; Paracetamol
  • Indications Alzheimer's disease
  • Focus Pharmacokinetics
  • Sponsors Bristol-Myers Squibb

Most Recent Events

  • 01 Oct 2025 Status changed from active, no longer recruiting to completed.
  • 14 Aug 2025 Planned End Date changed from 4 Aug 2025 to 5 Sep 2025.
  • 14 Aug 2025 Planned primary completion date changed from 4 Aug 2025 to 5 Sep 2025.

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