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A Phase 2b/3 Adaptive, Randomized, Active-controlled Study Evaluating the Efficacy, Safety, and Tolerability of Povetacicept Versus Calcineurin Inhibitor in the Treatment of Primary Membranous Nephropathy

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Trial Profile

A Phase 2b/3 Adaptive, Randomized, Active-controlled Study Evaluating the Efficacy, Safety, and Tolerability of Povetacicept Versus Calcineurin Inhibitor in the Treatment of Primary Membranous Nephropathy

Status: Recruiting
Phase of Trial: Phase II/III

Latest Information Update: 26 Feb 2026

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At a glance

  • Drugs Povetacicept (Primary) ; Tacrolimus
  • Indications IgA nephropathy; Membranous glomerulonephritis
  • Focus Registrational; Therapeutic Use
  • Acronyms OLYMPUS
  • Sponsors Vertex Pharmaceuticals

Most Recent Events

  • 28 Oct 2025 Status changed from not yet recruiting to recruiting.
  • 02 Oct 2025 Status changed from planning to not yet recruiting.
  • 12 May 2025 New trial record

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