Trial Profile

A Phase 3, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Sac-TMT (Sacituzumab Tirumotecan, MK-2870) Followed by Carboplatin/Paclitaxel vs Chemotherapy, Both in Combination With Pembrolizumab as Neoadjuvant Therapy for High-Risk, Early-Stage, Triple-Negative Breast Cancer or Hormone Receptor-low Positive/Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer

Status: Not yet recruiting

Phase of Trial: Phase III

Latest Information Update: 20 May 2025

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At a glance

Drugs Carboplatin (Primary) ; Sacituzumab Tirumotecan (Primary) ; Capecitabine; Cyclophosphamide; Dexamethasone; Doxorubicin; Epirubicin; Olaparib; Paclitaxel; Pembrolizumab
Indications Early breast cancer; HER2 negative breast cancer
Focus Registrational; Therapeutic Use
Sponsors Merck Sharp & Dohme

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