Trial Profile

A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)

Status: Not yet recruiting

Phase of Trial: Phase III

Latest Information Update: 03 Jun 2025

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At a glance

Drugs Cetuximab (Primary) ; Fluorouracil (Primary) ; Folinic acid (Primary) ; MK-1084 (Primary) ; Oxaliplatin (Primary) ; Bevacizumab
Indications Colorectal cancer
Focus Adverse reactions; Registrational; Therapeutic Use
Acronyms KANDLELIT-012
Sponsors Merck Sharp & Dohme

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