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A Phase 1 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of SION-451, and Multiple Dose Combinations of SION-451 and Complementary Modulators SION-2222 and SION-109 in Healthy Participants.

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Trial Profile

A Phase 1 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of SION-451, and Multiple Dose Combinations of SION-451 and Complementary Modulators SION-2222 and SION-109 in Healthy Participants.

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 30 Jun 2025

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At a glance

  • Drugs Galicaftor (Primary) ; SION 109 (Primary) ; SION 451 (Primary)
  • Indications Cystic fibrosis
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors Sionna Therapeutics

Most Recent Events

  • 30 Jun 2025 Status changed from planning to not yet recruiting.
  • 11 Jun 2025 New trial record
  • 04 Jun 2025 According to Sionna Therapeutics media release, company is on track to initiate the trial in the second half of 2025 with topline data expected in mid-2026

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