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JACOB: Joint Administration of cDNA for TP53, checkpOint Inhibition and Boost/Hypofractionated Radiation. A Phase 0/1 Study in Children With Recurrent, Progressive or Refractory CNS Malignancies

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Trial Profile

JACOB: Joint Administration of cDNA for TP53, checkpOint Inhibition and Boost/Hypofractionated Radiation. A Phase 0/1 Study in Children With Recurrent, Progressive or Refractory CNS Malignancies

Status: Not yet recruiting
Phase of Trial: Phase 0

Latest Information Update: 18 Jun 2025

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At a glance

  • Drugs SGT 53 (Primary) ; Nivolumab
  • Indications CNS cancer; Ependymoma; Glioma; Medulloblastoma; Sarcoma
  • Focus Adverse reactions
  • Acronyms JACOB

Most Recent Events

  • 18 Jun 2025 New trial record

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