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A Phase 1, Two Parts, Open-label, Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt (EYP651) in Healthy Volunteers and Evaluation of Potential Drug-Drug Interactions

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Trial Profile

A Phase 1, Two Parts, Open-label, Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt (EYP651) in Healthy Volunteers and Evaluation of Potential Drug-Drug Interactions

Status: Not yet recruiting
Phase of Trial: Phase I

Latest Information Update: 10 Dec 2025

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At a glance

  • Drugs EYP 651 (Primary) ; Vonafexor (Primary)
  • Indications Diabetic nephropathies; Hepatitis B; Hereditary nephritis; Kidney disorders; Non-alcoholic steatohepatitis
  • Focus Pharmacokinetics
  • Sponsors ENYO Pharma

Most Recent Events

  • 13 Oct 2025 Status changed from planning to not yet recruiting.
  • 19 Jun 2025 New trial record
  • 12 Jun 2025 According to ENYO Pharma media release, company has finalized its Series C financing round with a 6 million euro investment from Vesalius Biocapital IV, bringing the total Series C raise to 32 million euro which will extend ENYO's cash runway through the second half of 2026 and enables the initiation of this study.

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